Safety of Very Low Low-Density Lipoprotein Cholesterol Levels With Alirocumab
نویسندگان
چکیده
منابع مشابه
Safety of Very Low Low-Density Lipoprotein Cholesterol Levels With Alirocumab: Pooled Data From Randomized Trials.
BACKGROUND Proprotein convertase subtilisin/kexin type 9 monoclonal antibodies can reduce low-density lipoprotein cholesterol (LDL-C) to very low levels when added to background lipid-lowering therapy. OBJECTIVES The safety of alirocumab was evaluated in patients with at least 2 consecutive LDL-C values <25 or <15 mg/dl in the ODYSSEY program, with follow-up as long as 104 weeks. METHODS Po...
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BACKGROUND As the approach to low-density lipoprotein cholesterol (LDL-C) lowering becomes increasingly intensive, accurate assessment of LDL-C at very low levels warrants closer attention in individualized clinical efficacy and safety evaluation. We aimed to assess the accuracy of LDL-C estimation at very low levels by the Friedewald equation, the de facto clinical standard, and compare its ac...
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OBJECTIVES We sought to evaluate the significance of high-density lipoprotein cholesterol (HDL-C) in the context of low low-density lipoprotein cholesterol (LDL-C). BACKGROUND Earlier studies support an inverse correlation between circulating HDL-C and coronary risk in patients with normal or elevated LDL-C. METHODS This study involved 4,188 patients attending the Palo Alto Veterans Adminis...
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This manuscript was presented in part at the 31st Annual Meeting of the Council on Arteriosclerosis, American Society for the Study of Arteriosclerosis, American Heart Association. 1977. Circulation. 56(Suppl. III): 22. (Abstr.) Received for publication 2 December 1977 and in revised form 9 February 1978. and apoC) contained by negative staining, many disklike structures. The study demonstrated...
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International clinical practice guidelines on dyslipidemia emphasize the importance of matching the use and intensity of statin therapy with the absolute risk of atherosclerotic cardiovascular disease (CVD). Indeed, independent of the baseline level of dyslipidemia, patients who have entered the intervention arms of randomized clinical trials of statin therapy with similar absolute risks of CVD...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2017
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2016.11.037